Immunohistology of lymph nodes draining local skin reactions (chancres) in sheep infected with Trypanosoma congolense.
J Comp Pathol
; 105(1): 27-35, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1717523
ABSTRACT
Marked enlargement of lymph nodes draining local skin reactions (chancres) occurred in sheep following intradermal inoculation of cultured metacyclic forms of Trypanosoma congolense. Histologically, these lymph nodes were characterized by follicular hypertrophy and hyperplasia, compression and relative reduction of the paracortical areas and expansion of the medullary regions. Immunohistochemical staining with monoclonal antibodies to ovine lymphocyte subsets and Fc receptor (FcR) bearing macrophages, revealed increased expression of B cells (CD45R+), major histocompatibility complex (MHC) Class II, FcR+ macrophages, and CD1+ cells in the cortical and paracortical areas. The paracortical areas were found to be sparsely populated by CD5+, CD4+ and CD8+ cells, while the medullary areas contained numerous CD8+ cells and FcR+ macrophages. FcR+ macrophages were also present in cortical trabecular and subcapsular sinuses. As the chancre regressed, lymph node reactivity also subsided and fewer B cell follicles were observed and there was decreased expression of CD45R+ and MHC Class II+ cells.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Tripanossomíase Africana
/
Trypanosoma congolense
/
Linfonodos
Limite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Reino Unido