Photodynamic treatment versus photodynamic treatment associated with systemic steroids for idiopathic choroidal neovascularisation.
Br J Ophthalmol
; 91(5): 620-3, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17202205
ABSTRACT
AIM:
To compare photodynamic therapy (PDT) with PDT associated with systemic steroids (SS) for the control of juxta/subfoveal idiopathic choroidal neovascularisation (ICNV).METHODS:
Patients with juxta/subfoveal ICNV were randomised and then treated. Visual gain and loss were defined as improvement in or worsening for two or more lines of best-corrected visual acuity (BCVA), respectively. Choroidal neovascularisation size after treatment was classified as "increased" and "reduced" if it was increased or reduced by >200 microm(2), respectively.RESULTS:
10 patients were treated with PDT, 10 with SS followed by PDT. The median follow-up time was 22 and 21 months for the "steroid+PDT group" and the "PDT group", respectively. At 1 year, in the PDT group, five patients had stable/improved BCVA, and five became worse; the mean number of PDT was 2.3; in the steroid+PDT group, all patients were stable/improved and the mean number of PDT was 1.2. The difference between the two groups was significant (p<0.05). At 1 year, the ICNV size after treatment was better in the steroid+PDT group than in the PDT group (p<0.05).CONCLUSION:
The use of SS before PDT has shown better BCVA outcome than PDT alone (p<0.05), reducing the mean number of PDT applications (1.2 vs 2.3, respectively), with smaller scar size.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Prednisolona
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Corticosteroides
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Neovascularização de Coroide
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Humans
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Middle aged
Idioma:
En
Revista:
Br J Ophthalmol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália