Combined thrombophilic mutations in women with unexplained recurrent miscarriage.
Am J Reprod Immunol
; 57(2): 133-41, 2007 Feb.
Article
em En
| MEDLINE
| ID: mdl-17217367
ABSTRACT
PROBLEM:
To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group. METHOD OF STUDY Genomic analysis using polymerase chain reaction (PCR) was carried out in patients with two or more miscarriages and controls for Factor V Leiden, Factor V A1299H (HR2), Factor II G20210A, MTHFR C677T and MTHFR A1298C. Secondary analyses were made for number of miscarriages and gestational age at miscarriage.RESULTS:
None the mutations was associated with significantly increased risk for recurrent miscarriage. The prevalence of combined thrombophilias (4/88 versus 2/88) did not increase the risk for miscarriage (OR 2.04, 95% CI 0.36-11.47). Although virtually all patients with thrombophilia had miscarriagesCONCLUSIONS:
Combinations of the five thrombophilic mutations studied are an uncommon event with heterogeneous pattern and they do not significantly increase the risk for miscarriage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aborto Habitual
/
Trombofilia
/
Mutação
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Reprod Immunol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Grécia