Vulnerability of folate in plasma and bone marrow to total body irradiation in mice.
Int J Radiat Biol
; 83(1): 65-71, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17357441
ABSTRACT
PURPOSE:
To examine how folate status in a body is influenced by oxidative stress. MATERIAL ANDMETHODS:
Mice were given total body irradiation (TBI) by X-ray, and changes in the concentration of folate were compared to those in vitamins C and E.RESULTS:
In a time-dependent study, folate in plasma and bone marrow decreased from 5 h until 120 h post-TBI at 3 Gy. Folate in plasma and bone marrow decreased in a dose-dependent manner at 24 h. Marked decreases of vitamins C and E were also detected in bone marrow, but not in plasma even at 10 Gy of TBI. The susceptibility of plasma folate by irradiation was confirmed by an in vitro exposure study. Neither vitamins C and E nor folate were decreased in the liver by TBI.CONCLUSION:
It is suggested that folate is vulnerable to oxidative stress, and folate may need to be evaluated, particularly for TBI or radiotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Irradiação Corporal Total
/
Estresse Oxidativo
/
Ácido Fólico
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Int J Radiat Biol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão