Contribution of diffusion tensor MR imaging in detecting cerebral microstructural changes in adults with neurofibromatosis type 1.
AJNR Am J Neuroradiol
; 28(4): 773-6, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17416837
ABSTRACT
BACKGROUND AND PURPOSE:
After an early progression of signal intensity changes in T2-weighted MR images, also known as "neurofibromatosis bright objects," in patients with neurofibromatosis type 1 (NF-1), there is a tendency toward regression or even disappearance in early adulthood. The purpose of this study was to investigate whether adult patients with NF-1 exhibit generalized microstructural alterations even in normal-appearing brain regions. MATERIALS ANDMETHODS:
Conventional and diffusion tensor MR imaging of the brain was obtained in 10 adult patients with NF-1 and 10 age-matched healthy volunteers. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in brain stem, basal ganglia, thalamus, corpus callosum, and frontal and parietooccipital white matter regions.RESULTS:
Significantly increased ADC and decreased FA values were found in all regions of interest and in all patients with NF-1, irrespective of their scholastic achievement and subsequent professional performance, compared with control subjects (P < .001). There were no significant correlations with the age (P > .1) or with the lateralization between brain hemispheres (P > .05).CONCLUSION:
Diffusion tensor imaging reveals globally elevated FA and decreased ADC values in the mature brains of patients with NF-1, which is most likely a consequence of diffuse and basic alterations in cerebral microstructure that result from the underlying gene mutation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Neurofibromatose 1
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Imagem de Difusão por Ressonância Magnética
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Suíça