Management of bioburden with a burn gel that targets nociceptors.
J Wound Care
; 16(4): 157-64, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17444381
ABSTRACT
AIM:
To assess the effectiveness of RescuDerm, an amorphous, water-soluble burn gel in controlling Pseudomonas aeruginosa growth in rat full-thickness wounds contaminated with 10(3), 10(5) or 10(7) CFU/g tissue.METHOD:
Wounds were treated daily for 72 hours with a placebo gel, a 5% w/w mafenide acetate gel (MAF), or with four modalities of RescuDerm application.RESULTS:
All RescuDerm treatments were equally effective within 24 hours in preventing further Pseudomonas aeruginosa growth in wounds contaminated with 10(3) CFU/g tissue. Pseudomonas aeruginosa levels remained at or below this baseline count for 72 hours in all but one of the RescuDerm treatments. The bioburdens in MAF-treated wounds were negligible, averaging 0.14 +/- 0.09 log10 CFU/g tissue. While RescuDerm and MAF remained bacteriostatic in wounds contaminated with 10(5) CFU/g tissue, this property disappeared at higher bioburdens.CONCLUSION:
RescuDerm can be used for the management of cutaneous injuries sustained in environments deemed marginally or moderately contaminated. Heavily contaminated wounds would require irrigation prior to application to reduce their bioburden below 10(5) CFU/g tissue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecção dos Ferimentos
/
Nociceptores
/
Queimaduras
/
Mafenida
/
Anti-Infecciosos Locais
Limite:
Animals
Idioma:
En
Revista:
J Wound Care
Assunto da revista:
ENFERMAGEM
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Canadá