Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution.
J Exp Med
; 174(6): 1657-60, 1991 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-1744590
ABSTRACT
We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo-antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Antígenos H-2
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Suíça