Antielastin autoimmunity in tobacco smoking-induced emphysema.
Nat Med
; 13(5): 567-9, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17450149
ABSTRACT
Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fumar
/
Autoimunidade
/
Elastina
/
Enfisema
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos