Germline histone dynamics and epigenetics.
Curr Opin Cell Biol
; 19(3): 257-65, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17467256
ABSTRACT
Germ cells have the same DNA sequence as somatic cells, but the processes that act on their chromatin are different. Germline chromatin undergoes a series of dramatic remodeling events during the life cycle of an organism. Different aspects of germline chromatin have been dissected in recent years, such as differences between the sex chromosomes and autosomes in histone variants and modifications. Excitingly, histone dynamics have recently been implicated in imprinted X inactivation and genomic imprinting processes that are independent of DNA methylation. Taken together with observations of core histone retention in mature sperm of diverse animals, histones have become prime candidates for mediating germline epigenetic inheritance.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Epigênese Genética
/
Células Germinativas
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos