Does topical N-acetylcysteine application after myringotomy cause severe otorrhea?
Kulak Burun Bogaz Ihtis Derg
; 17(1): 22-5, 2007.
Article
em En
| MEDLINE
| ID: mdl-17483607
ABSTRACT
OBJECTIVES:
The effect of topical N-acetylcysteine (NAC) application was investigated on the healing of acute experimental tympanic membrane perforations. MATERIALS ANDMETHODS:
Twenty guinea pigs were used in this study. Under intraperitoneal ketamine anesthesia, incisional myringotomies were performed in the posterosuperior quadrant of the tympanic membranes with a straight otologic hook. The diameter of the perforations was approximately 2 mm. Perforations in both ears were treated with freshly prepared sponges soaked in either 0.1 ml 0.9% NaCl solution (10 control animals) or 0.6 mg/0.1 ml NAC (10 animals) for three consecutive days. All the tympanic membranes were examined by otomicroscopy on the third, fifth, seventh, and ninth days.RESULTS:
In the control group, all the perforations were completely closed at the end of nine days. During the same period, only 40% of the perforations were completely closed in the NAC group. The remaining ears exhibited otorrhea by the third day.CONCLUSION:
N-acetylcysteine may cause severe otorrhea in the healing process of tympanic membrane perforations. Further studies including histopathological examinations are required to elucidate this condition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otite Média Supurativa
/
Acetilcisteína
/
Anti-Inflamatórios não Esteroides
/
Perfuração da Membrana Timpânica
Limite:
Animals
Idioma:
En
Revista:
Kulak Burun Bogaz Ihtis Derg
Assunto da revista:
AUDIOLOGIA
/
OTORRINOLARINGOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Turquia