Improved antimicrobial peptides based on acyl-lysine oligomers.
Nat Biotechnol
; 25(6): 657-9, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17529972
ABSTRACT
We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peritonite
/
Peptídeos Catiônicos Antimicrobianos
/
Lisina
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Biotechnol
Assunto da revista:
BIOTECNOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Israel