Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases.
Cells Tissues Organs
; 185(1-3): 111-5, 2007.
Article
em En
| MEDLINE
| ID: mdl-17587816
ABSTRACT
Prostate cancer is associated with significant mortality once the tumour has spread outside the gland. Epithelial-mesenchymal transition (EMT) has been proposed to facilitate this dissemination of tumour cells. In this article we summarize the evidence for EMT in prostate cancer, drawing on the expression of EMT-related markers and the functions of factors known to induce EMT in other systems. We also discuss our recent findings that two members of the tissue kallikrein family of serine proteases, prostate-specific antigen (PSA/KLK3) and kallikrein-related peptidase 4 (KLK4), lead to EMT-like changes in PC3 prostate cancer cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Calicreínas
/
Epitélio
/
Mesoderma
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Cells Tissues Organs
Assunto da revista:
ANATOMIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Austrália