Cognitive, anxiety and mood disorders in the fragile X-associated tremor/ataxia syndrome.
Gen Hosp Psychiatry
; 29(4): 349-56, 2007.
Article
em En
| MEDLINE
| ID: mdl-17591512
ABSTRACT
OBJECTIVE:
We evaluated patients with fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder associated with a CGG repeat expansion in the premutation range in the fragile X mental retardation 1 (FMR1) gene.METHODS:
Neurological, psychiatric and neuropsychological evaluations were performed on 15 male patients with FXTAS.RESULTS:
Seven cases were diagnosed with dementia, and seven others were diagnosed with mood and/or anxiety disorders. Twelve subjects demonstrated deficits on neuropsychological testing.CONCLUSIONS:
Physicians assessing dementia patients are urged to consider this newly described syndrome, especially in patients with dementia associated with a movement disorder and in those with a family history of mental retardation. If FXTAS is a possible diagnosis, physicians may carry out FMR1 DNA testing; patients who test positive on DNA testing should undergo magnetic resonance imaging, be referred to neurology and receive genetic counseling.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Ataxia
/
Tremor
/
Transtornos Cognitivos
/
Transtornos do Humor
/
Síndrome do Cromossomo X Frágil
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Gen Hosp Psychiatry
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos