Combined directed ortho Metalation/Suzuki-Miyaura cross-coupling strategies. Regiospecific synthesis of chlorodihydroxybiphenyls and polychlorinated biphenyls.
J Org Chem
; 72(16): 5960-7, 2007 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-17616228
The Directed ortho Metalation (DoM)/Suzuki-Miyaura cross-coupling strategy is applied for the regiospecific construction of all isomeric monochloro and selected dichloro and trichloro 2,3-dihydroxybiphenyls (DHBs). The combined methodology highlights iterative DoM processes, hindered Suzuki-Miyaura couplings, and advantages in diversity in approaches from commercial starting materials leading to provision of chloro-DHBs as single isomers in high purity and on a gram scale. The syntheis of several PCBs are also reported.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Bifenilo
/
Catecóis
/
Química Orgânica
/
Bifenilos Policlorados
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Áustria