The pre-Bötzinger oscillator in the mouse embryo.
J Physiol Paris
; 100(5-6): 284-9, 2006.
Article
em En
| MEDLINE
| ID: mdl-17628453
ABSTRACT
Studies of the sites and mechanisms involved in mammalian respiratory rhythm generation point to two clusters of rhythmic neurons forming a coupled oscillator network within the brainstem. The location of these oscillators, the pre-Bötzinger complex (preBötC) at vagal level, and the para-facial respiratory group at facial level, probably result from regional patterning schemes specifying neural types in the hindbrain during embryogenesis. Here, we report evidence that the preBötC oscillator (i) is first active at embryonic stages, (ii) originates in the post-otic hindbrain neural tube and (iii) requires the glutamate vesicular transporter 2 for rhythm generation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periodicidade
/
Centro Respiratório
/
Bulbo
/
Embrião de Mamíferos
Limite:
Animals
Idioma:
En
Revista:
J Physiol Paris
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
França