Bidirectional MHC molecule exchange between migratory and resident dendritic cells.
J Leukoc Biol
; 82(4): 861-8, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17634280
ABSTRACT
Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules and that a proportion of injected DCs acquired host MHC molecules. These observations suggest that a bidirectional MHC molecule exchange occurs between migratory and resident DCs, a mechanism that may amplify antigen presentation in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Comunicação Celular
/
Movimento Celular
/
Antígenos de Histocompatibilidade
/
Linfonodos
Limite:
Animals
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Bélgica