Donor denervation and elimination of Kupffer cells affect expression of P-selectin and ICAM-1 in liver graft.
Hepatobiliary Pancreat Dis Int
; 6(4): 379-82, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17690033
ABSTRACT
BACKGROUND:
The non-function and dysfunction of primary liver graft likely involves dependence on Kupffer cells and hepatic innervation. The present experiment was designed to study the expression of P-selectin and intercellular adhesion molecule-1 (ICAM-1) mRNA in liver graft and to elucidate the role of Kupffer cells and the sympathetic nerve of the liver in down-regulating this expression.METHODS:
Donor rats were given hexamethonium, a sympathetic ganglionic blocking agent, and/or gadolinium chloride, an inhibitor of Kupffer cells. Then the changes of graft P-selectin and ICAM-1 mRNA expression were measured after liver transplantation.RESULTS:
The expressions of P-selectin and ICAM-1 mRNA were increased after liver transplantation, and down-regulated by liver denervation and elimination of Kupffer cells.CONCLUSIONS:
Live donor denervation and elimination of Kupffer cells down-regulated the expressions of P-selectin and ICAM-1 mRNA in grafts. This may decrease graft ischemia/reperfusion injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Transplante de Fígado
/
Molécula 1 de Adesão Intercelular
/
Selectina-P
/
Células de Kupffer
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Hepatobiliary Pancreat Dis Int
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2007
Tipo de documento:
Article