Persistent reduction of ischemic mitral regurgitation by papillary muscle repositioning: structural stabilization of the papillary muscle-ventricular wall complex.
Circulation
; 116(11 Suppl): I259-63, 2007 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-17846314
ABSTRACT
BACKGROUND:
Recurrent ischemic mitral regurgitation (IMR) is frequent despite initial reduction by annuloplasty because continued LV remodeling increases tethering to the infarcted papillary muscle (PM). We have previously shown that PM repositioning by an external patch device can acutely reduce IMR. In this study, we tested the hypothesis that IMR reduction persists despite possible continued LV remodeling. METHODS ANDRESULTS:
In 7 sheep, we used a chronic ischemic posterior infarct model that produces LV dilatation and MR over 10 weeks. An epicardial patch device was adjusted under echo guidance to reduce MR, with follow-up over a further 8 weeks and evaluation by 3D echo and sonomicrometry. In all 7 sheep, moderate IMR resolved with acute patch application and PM repositioning (6.5+/-1.8 mm to 0.6+/-1.3 mm proximal jet width, P<0.001) without decrease in LVEF (43+/-3% to 44+/-8%). Eight weeks after PM repositioning, MR was not significantly greater (0.6+/-1.3 mm versus 1.0+/-1.0 mm, P=NS) despite an increase in LV volumes in 3 animals (2 had increases of 50+/-15%). On average, LV volumes did not change significantly (ESV 46+/-8 mL versus 49+/-15 mL; P=NS and EDV 85+/-16 mL versus 89+/-30 mL; P=NS). LVEF was unchanged from acute to chronic patch (44+/-8% versus 43+/-8%). Contractility as end-systolic elastance did not decrease from the chronic MI to the acute and chronic patch stages, nor were there any significant changes in dP/dt, LV stiffness constant, or time constant of LV relaxation (Tau).CONCLUSION:
PM repositioning is persistently effective in reducing moderate chronic IMR, even when LV volume increases. This may reflect structural stabilization by an external patch device of the papillary muscle-LV wall complex that controls mitral valve tethering.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Músculos Papilares
/
Isquemia Miocárdica
/
Disfunção Ventricular Esquerda
/
Procedimentos Cirúrgicos Cardíacos
/
Insuficiência da Valva Mitral
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Circulation
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos