Synthesis, structure and cytotoxicity of triphenylphosphinegold(I) sulfanylpropenoates.
J Inorg Biochem
; 102(2): 184-92, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-17870173
ABSTRACT
The reaction of triphenylphosphinegold(I) chloride in ethanol in a 11 molar ratio with the 3-(aryl)-2-sulfanylpropenoic acids H(2)xspa [x p=3-phenyl-, Clp=3-(2-chlorophenyl)-, -o-mp=3-(2-methoxyphenyl)-, -p-mp=3-(4-methoxyphenyl)-, -o-hp=3-(2-hydroxyphenyl)-, -p-hp=3-(4-hydroxyphenyl)-, diBr-o-hp=3-(3,5-dibromo-2-hydroxyphenyl)-, f=3-(2-furyl)-, t=3-(2-thienyl)-, -o-py=3-(2-pyridyl)-; spa=2-sulfanylpropenoato] gave compounds of the type [Au(PPh(3))(Hxspa)], which were isolated and characterized as solids by elemental analysis, IR spectroscopy and FAB mass spectrometry and in solution by (1)H, (13)C and (31)P NMR spectroscopy. The structures of the complexes [Au(PPh(3))(HClpspa)], [Au(PPh(3))(H-o-mpspa)] and [Au(PPh(3))(H-p-mpspa)].2/3C(3)H(6)O were determined by X-ray diffractometry. Hydrogen bonding was found along with Au-S and Au-P bonds in all cases and weak pi-pi stacking was found in the H-p-mpspa derivative. The in vitro antitumour activities against the HeLa-229, A2780 and A2780cis cell lines were determined for all complexes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organoáuricos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Espanha