pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia.
Med Oral Patol Oral Cir Bucal
; 12(6): E435-9, 2007 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-17909509
ABSTRACT
OBJECTIVE:
To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx). MATERIALS ANDMETHODS:
A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at To basal condition; T1 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T2 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378 equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level.RESULTS:
The highest values of sodium bicarbonate were observed at T2, with salivary pH levels remaining within neutrality ranges, diminishing slightly in T1. CONCLUSION. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m2 Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saliva
/
Metotrexato
/
Bicarbonato de Sódio
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Antimetabólitos Antineoplásicos
Tipo de estudo:
Guideline
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Med Oral Patol Oral Cir Bucal
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article