Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey.
Eur Neurol
; 59(1-2): 67-70, 2008.
Article
em En
| MEDLINE
| ID: mdl-17917461
ABSTRACT
BACKGROUND AND AIMS:
We investigated the prevalence of this multidrug resistance 1 gene (MDR1) polymorphism in drug-responsive versus drug-resistant epilepsy patients treated with carbamazepine (CBZ), which is a substrate of this protein.METHODS:
We genotyped the C3435T variant of MDR1 in 97 patients treated with CBZ monotherapy who had been on stable doses for more than 1 month. Our control group included 174 healthy individuals. Plasma CBZ concentrations were also measured using fluorescence polarization immunoassay.RESULTS:
We could not demonstrate any statistically significant relationship with the genotypes among drug-resistant patients (n = 44). The frequency of the homozygous mutant (TT) genotype was 15% in drug-responsive patients, 11.3% in drug-resistant patients and 25.8% in the control group. We also did not observe any significant correlation between the presence of a specific allele and CBZ plasma level/dose index.CONCLUSION:
Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Resistência a Medicamentos
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Epilepsia
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Eur Neurol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Turquia