Effects of different nutritional support on lung mechanics and remodelling in undernourished rats.
Respir Physiol Neurobiol
; 160(1): 54-64, 2008 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-17919996
ABSTRACT
This study investigated the impact of three different oral nutritional support regimens on lung mechanics and remodelling in young undernourished Wistar rats. In the nutritionally deprived group, rats received one-third of their usual daily food consumption for 4 weeks. Undernourished rats were divided into three groups receiving a balanced, glutamine-supplemented, or long-chain triglyceride-supplemented diet for 4 weeks. In the two control groups, rats received food ad libitum for 4 (C4) or 8 weeks. Lung viscoelastic pressure and static elastance were higher in undernourished compared to C4 rats. After refeeding, lung mechanical data remained altered except for the glutamine-supplemented group. Undernutrition led to a reduced amount of elastic and collagen fibres in the alveolar septa. Elastic fibre content returned to control with balanced and glutamine-supplemented diets, but increased with long-chain triglyceride-supplemented diet. The amount of collagen fibre augmented independent of nutritional support. In conclusion, glutamine-supplemented diet is better at reducing morphofunctional changes than other diets after 4 weeks of refeeding.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mecânica Respiratória
/
Apoio Nutricional
/
Desnutrição
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil