Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice.
Psychopharmacology (Berl)
; 196(1): 1-13, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-17934722
ABSTRACT
PURPOSE:
This study investigated the dose-effect relationship of modafinil administration on contextual memory processes, in parallel with the measurements of plasma corticosterone levels in acutely stressed mice. MATERIALS ANDMETHODS:
Memory was first evaluated in normal (nonstressed) mice either in contextual (CSD) or spatial (SSD) tasks. Thus, C57 Bl/6 Jico mice learned two consecutive discriminations (D1 and D2) in a four-hole board. The discriminations occurred on either distinct (CSD) or identical (SSD) floors (internal contextual cues). All mice received a vehicle intraperitoneal injection before learning and were injected 24 h later (20 min before the test session) either with vehicle or modafinil.RESULTS:
Results showed that modafinil-treated mice behaved similarly as vehicles in the spatial SSD task, whereas in contrast, memory of the first-learned discrimination (D1) in the CSD task was enhanced by a 32- but not a 16-mg/kg modafinil dose. Hence, we studied the effect of a pretest acute stress (electric footshocks) specifically on D1 performance in modafinil-treated subjects. Immediately after behavioral testing, blood was sampled to measure plasma corticosterone levels.CONCLUSIONS:
Results showed that (1) stress significantly improved performance in vehicles, (2) stress decreased the efficiency threshold of modafinil, as performance was enhanced at the low dose (16 mg/kg), whereas this enhancement was obtained for the high dose (32 mg/kg) under nonstress conditions, (3) the performance was impaired at the high (32 mg/kg) dose, and (4) modafinil significantly reduced the magnitude of the stress-induced corticosterone secretion, mainly at the dose of 32 mg/kg.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientação
/
Comportamento Apetitivo
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Rememoração Mental
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Aprendizagem por Associação
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Estresse Psicológico
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Compostos Benzidrílicos
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Corticosterona
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Aprendizagem por Discriminação
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Estimulantes do Sistema Nervoso Central
Limite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França