Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.
Adv Exp Med Biol
; 603: 225-34, 2007.
Article
em En
| MEDLINE
| ID: mdl-17966419
ABSTRACT
Control of Yops secretion in pathogenic Yersinia is achieved at several levels. These levels likely include transcriptional, post-transcriptional, translational and secretional controls. Secretion control appears to be mediated by two pathways. One pathway involves YopN and proteins that interact with YopN. The second pathway consists of LcrG and its interaction with LcrV. LcrV is a postive regulator of Yops secretion that exerts control over Yops secretion by negating the secretion blocking role of LcrG. However, the intersection of these two control pathways is not understood. Recent work has allowed the development of a speculative model that brings YopN-mediated and LcrG-LcrV-mediated control together in the context of the ability of the needle complex to respond to Ca2+.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Yersinia pestis
/
Proteínas Citotóxicas Formadoras de Poros
/
Proteínas de Membrana
/
Antígenos de Bactérias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos