The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage.
Ulus Travma Acil Cerrahi Derg
; 13(4): 268-73, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17978907
ABSTRACT
BACKGROUND:
To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model.METHODS:
Gastric ulcers were induced by oral ingestion of indomethacin. Thirty rats were used in the study. The rats were divided into 3 groups, and given either SC (n=10) at a dose of 50 mg/kg or omeprazole (n=10), or no treatment (n=10, the control group). In addition to the measurements of ulceration areas, the sum of gastric tissue nitrite (NO2-) and nitrate (NO3-) were evaluated as an indicator of gastric tissue NO level. All the measurements were done at 6th hour of oral administration of indomethacin.RESULTS:
The mean values of ulceration areas were 4.0+/-2.31, 3.0+/-2.00, and 21.4+/-8.43 in the SC, omeprazole and control groups, respectively. The mean values of ulceration areas in the SC-treated group was lower than that of the control group. The contents of NO were 32.2+/-3.05, 24.8+/-3.23 and 21.0+/-0.82 (micromol/g protein) in gastric tissue in indomethacin, SC, omeprazole and control groups, respectively, The content of NO in the SC-treated groups was significantly higher than control group (p<0.001).CONCLUSION:
Sildenafil citrate may have a role in protecting gastric mucosa from the damage caused by indomethacin. This effect may be associated with the increased level of NO in gastric tissue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Fosfodiesterase
/
Piperazinas
/
Úlcera Gástrica
/
Sulfonas
/
Antiulcerosos
Limite:
Animals
Idioma:
En
Revista:
Ulus Travma Acil Cerrahi Derg
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Turquia