Activity of dihydrofolate reductase inhibitors on the hepatic stages of Plasmodium yoelii yoelii in vitro.
Trans R Soc Trop Med Hyg
; 85(6): 725-6, 1991.
Article
em En
| MEDLINE
| ID: mdl-1801335
The effects of the dihydrofolate reductase inhibitors proguanil and chlorproguanil, their active metabolites cycloguanil and chlorcycloguanil, and pyrimethamine, against the hepatic stages of Plasmodium yoelii yoellii were investigated in cultured BALB/c mouse hepatocytes. Proguanil was inactive at concentrations of 10(-8) M, whereas the other compounds were fully active at this and lower concentrations. Chlorcycloguanil was the most active compound and almost completely inhibited schizont development in concentrations as low as 10(-12) M.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium yoelii
/
Antagonistas do Ácido Fólico
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Suécia