A case of acute myeloid leukemia with inv(16)(p13q22) reveals a novel MYH11 breakpoint and a new CBF beta-MYH11 transcript variant.
Haematologica
; 92(10): 1433-4, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-18024381
ABSTRACT
We present a case of acute myeloid leukemia (AML) with a cytogenetically typical inv(16)(p13q22), M4 morphology and eosinophilia. However, studies revealed a CBF beta-MYH11 fusion transcript which did not correspond to any of the 10 known variants. Subsequent sequencing revealed a new in-frame transcript variant resulting from a novel MYH11 exon 32 breakpoint and a seven base insertion at the fusion point. The patient remains in complete remission following standard protocols. Prognostic implications cannot, therefore, be evaluated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Cromossomos Humanos Par 16
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Leucemia Mieloide Aguda
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Proteínas de Fusão Oncogênica
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Revista:
Haematologica
Ano de publicação:
2007
Tipo de documento:
Article