Histidine kinases as antimicrobial targets: prospects and pitfalls.
Mini Rev Med Chem
; 7(11): 1144-54, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-18045218
ABSTRACT
Histidine kinases are ubiquitous molecular sensors that are used by bacteria to detect and respond to a myriad of environmental signals. They are attractive antimicrobial targets because of their roles in mediating the virulence of pathogenic organisms, as well as the ability of bacteria to resist host defenses and develop resistance to antibiotics. In this review, we discuss the challenges involved in developing specific inhibitors of this highly diverse group of kinases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Sistemas de Liberação de Medicamentos
/
Anti-Infecciosos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mini Rev Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Austrália