H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44.
J Virol
; 82(4): 2028-32, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18077718
ABSTRACT
Antiviral immune defenses involve natural killer (NK) cells. We previously showed that the NK-activating receptor NKp44 is involved in the functional recognition of H1-type influenza virus strains by NK cells. In the present study, we investigated the interaction of NKp44 and the hemagglutinin of a primary influenza virus H5N1 isolate. Here we show that recombinant NKp44 recognizes H5-expressing cells and specifically interacts with soluble H5 hemagglutinin. H5-pseudotyped lentiviral particles bind to NK cells expressing NKp44. Following interaction with target cells expressing H5, pseudotyped lentiviral particles, or membrane-associated H5, NK cells show NKp44-mediated induced activity. These findings indicate that NKp44-H5 interactions induce functional NK activation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Receptores Imunológicos
/
Glicoproteínas de Hemaglutininação de Vírus da Influenza
/
Virus da Influenza A Subtipo H5N1
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Israel