Preventive effects of perioperative parecoxib on post-discectomy pain.
Br J Anaesth
; 100(2): 256-62, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18079431
ABSTRACT
BACKGROUND:
Cyclooxygenase inhibitor treatment is viewed increasingly critical because of safety considerations, and there are several open questions on their optimal use.METHODS:
In a randomized placebo-controlled study in 320 patients undergoing discectomy, we administered parecoxib 40 mg either perioperatively (before operation and after operation), after operation (first dose given in the evening after surgery), or before operation (single parecoxib dose given 45 min before surgery). We measured the main outcome variables average pain score, morphine consumption, and opioid-related symptom distress at 25, 49, and 73 h after surgery.RESULTS:
Perioperative parecoxib significantly (i) improved the pain score compared with both placebo and postoperative parecoxib, (ii) decreased morphine consumption, and (iii) reduced the opioid-related symptom distress score. Neither a single preoperative dose nor postoperative parecoxib (first dose given in the evening after surgery) significantly improved morphine's analgesic effectiveness.CONCLUSIONS:
Perioperative parecoxib compared with postoperative parecoxib improves post-discectomy pain and results in a reduction in adverse effects associated with opioid therapy. Postoperative parecoxib, or a single pre-incisional parecoxib dose, does not significantly improve post-discectomy pain or opioid side-effects up to 3 days after surgery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Pós-Operatória
/
Inibidores de Ciclo-Oxigenase
/
Discotomia
/
Analgésicos não Narcóticos
/
Isoxazóis
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Revista:
Br J Anaesth
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Alemanha