Interleukin 1 beta gene polymorphism and risk of cervical cancer.
Int J Gynaecol Obstet
; 101(1): 47-52, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18154955
ABSTRACT
OBJECTIVE:
To determine whether a polymorphism at position +3953 in exon 5 of the lL-1beta gene (IL-1beta +3953), a condition associated with an increased risk for a number of inflammatory diseases, is also involved in the development of cervical cancer.METHOD:
We isolated DNA from peripheral blood in 150 women with cervical cancer and 200 healthy controls, and IL-1beta +3953 allele polymorphism was determined by polymerase chain reaction.RESULTS:
Genotypes A1/A2 and A2/A2+A1/A2 were associated with increased risk of cervical cancer (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.78-4.67; P<0.001 and OR, 2.85; 95% CI, 1.77-4.6; P<0.001, respectively). The risk in a passive smoker with A2/A2 or A1/A2 genotype was increased more than 5-fold (OR, 5.69; 95% CI, 2.61-12.50; P<0.001) compared with a nonsmoker with the A1/A1 genotype.CONCLUSION:
This study provides evidence of an association between lL-1beta +3953 polymorphism and risk of cervical cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Neoplasias do Colo do Útero
/
Interleucina-1beta
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Int J Gynaecol Obstet
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Índia