The role of the immune system in myelodysplasia: implications for therapy.
Semin Hematol
; 45(1): 39-48, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18179968
ABSTRACT
Patients with myelodysplastic syndrome (MDS) have intrinsic, usually acquired genetic defects in their hematopoietic stem cells, but some others exhibit T-cell-mediated inhibition of hematopoiesis and good responses to immunosuppression. In these cases, MDS shares a similar pathophysiology with aplastic anemia (AA). Here, we review the evidence supporting a role of the immune system in the pathophysiology of MDS and the results of clinical trials of immunosuppressive agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Sistema Imunitário
/
Imunossupressores
Limite:
Humans
Idioma:
En
Revista:
Semin Hematol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos