Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2.
Genetics
; 178(3): 1639-52, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18245828
ABSTRACT
Domestic species allow us to study dramatic evolutionary changes at an accelerated rate due to the effectiveness of modern breeding techniques and the availability of breeds that have undergone distinct selection pressures. We present a worldwide survey of haplotype variability around a known causative mutation in porcine gene IGF2, which increases lean content. We genotyped 34 SNPs spanning 27 kb in 237 domestic pigs and 162 wild boars. Although the selective process had wiped out variability for at least 27 kb in the haplotypes carrying the mutation, there was no indication of an overall reduction in genetic variability of international vs. European local breeds; there was also no evidence of a reduction in variability caused by domestication. The haplotype structure and a plot of Tajima's D against the frequency of the causative mutation across breeds suggested a temporal pattern, where each breed corresponded to a different selective stage. This was observed comparing the haplotype neighbor-joining (NJ) trees of breeds that have undergone increasing selection pressures for leanness, e.g., European local breeds vs. Pietrain. These results anticipate that comparing current domestic breeds will decisively help to recover the genetic history of domestication and contemporary selective processes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Seleção Genética
/
Variação Genética
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Haplótipos
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Fator de Crescimento Insulin-Like II
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Sus scrofa
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Mutação
Limite:
Animals
Idioma:
En
Revista:
Genetics
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Espanha