Effects of Cd(2+) on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area.
Toxicol Lett
; 176(3): 215-22, 2008 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-18248923
ABSTRACT
Cadmium (Cd(2+)) is a common pollutant that causes a wide variety of toxic effects on the central nervous system. However, the mechanism of Cd(2+) neurotoxicity remains to be elucidated. In the present study, we examined the effects of Cd(2+) on AMPA receptor-mediated synaptic transmission and short-term synaptic plasticity in hippocampal CA1 area, using whole-cell patch clamp technique. Cd(2+) significantly inhibited the peak amplitude of evoked EPSCs (eEPSCs) in a concentration-dependent manner and enhanced the short-term synaptic plasticity including paired-pulse facilitation and frequency facilitation. Cd(2+) also decreased the frequency and amplitude of spontaneous EPSCs (sEPSCs) but had no effect on those of miniature EPSCs (mEPSCs). These effects of Cd(2+) may involve a presynaptic mechanism of blockade of action potential-sensitive, calcium-dependent release of glutamate. In addition, Cd(2+) prolonged the decay time of both sEPSCs and mEPSCs, which suggested a postsynaptic action site of Cd(2+). This study demonstrates that Cd(2+) impairs the Schaffer collateral-commissural-CA1 glutamatergic synaptic transmission and short-term plasticity in rat hippocampal slices, which may be a possible contributing mechanism for the Cd(2+)-induced neurotoxic effects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de AMPA
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Cloreto de Cádmio
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Potenciais Pós-Sinápticos Excitadores
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Poluentes Ambientais
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Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
2008
Tipo de documento:
Article