CD4+ CD25+ regulatory T cells: a therapeutic target for liver diseases.
Expert Opin Ther Targets
; 12(3): 313-26, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18269341
ABSTRACT
BACKGROUND:
Regulatory T cells (Tregs) have been shown to play an important role in maintaining peripheral immune homeostasis by suppressing autoreactive and allergen-specific T cells and turning off the immune response after the pathogen has been cleared. However, in certain situations Tregs can impair effective immunity to some pathogens and tumour cells.OBJECTIVE:
To review the role of Tregs in liver pathology and to assess the potential to enhance or inhibit their function as applied to the treatment of liver disease.METHODS:
The literature was reviewed using standard indexing terms and incorporating publications up to and including those published in 2007. RESULTS/CONCLUSIONS:
Tregs are therapeutic targets for modulation in autoimmune disease and may provide new opportunities for application to human liver conditions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos CD4
/
Sistemas de Liberação de Medicamentos
/
Linfócitos T Reguladores
/
Subunidade alfa de Receptor de Interleucina-2
/
Hepatopatias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Opin Ther Targets
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
China