Retinal photocoagulation for proliferative sickle cell retinopathy: a prospective clinical trial with new sea fan classification.
Eur J Ophthalmol
; 18(2): 248-54, 2008.
Article
em En
| MEDLINE
| ID: mdl-18320518
ABSTRACT
PURPOSE:
To compare the clinical outcome of stage III proliferative sickle cell retinopathy (PSR) treated by peripheral retinal scatter photocoagulation to natural course disease.METHODS:
Long-term follow-up of 101 patients enrolled in a prospective trial of photocoagulation for PSR has been completed. Among 202 eyes of 101 patients enrolled at the University Eye Clinic of Créteil, 73 eyes showed a stage III PSR, which the authors further divided into five new grades (A, B, C, D, E) considering size, hemorrhage, fibrosis, and visible vessels. Grading was based on a three-mirror fundus examination, 360 degrees color photographs, and fluorescein angiography. Mean follow- up was 4 years.RESULTS:
Thirty-eight treated eyes and 35 untreated eyes were included in this study. The evolution was not statistically significant between treated and untreated groups concerning flat sea fan <1 MPS disc area (grade A) or elevated sea fan with partial fibrosis (grade C). Progression and regression were compared between the two groups for grade B, resulting statistically significant (p<0.05). Nine complications (13%) were observed, which only occurred in untreated patients with elevated sea fan and hemorrhage (grade B) or complete fibrosed sea fan with well defined vessels (grade E) (p<0.05).CONCLUSIONS:
These data suggest that patients with grade A or C new sea fan classification should not be initially treated but observed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traço Falciforme
/
Hemorragia Vítrea
/
Neovascularização Retiniana
/
Fotocoagulação a Laser
/
Talassemia beta
/
Doença da Hemoglobina SC
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur J Ophthalmol
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França