DNA mismatch repair: molecular mechanism, cancer, and ageing.
Mech Ageing Dev
; 129(7-8): 391-407, 2008.
Article
em En
| MEDLINE
| ID: mdl-18406444
ABSTRACT
DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important cellular functions. In its role in post-replication repair, MMR safeguards the genome correcting base mispairs arising as a result of replication errors. Loss of MMR results in greatly increased rates of spontaneous mutation in organisms ranging from bacteria to humans. Mutations in MMR genes cause hereditary nonpolyposis colorectal cancer, and loss of MMR is associated with a significant fraction of sporadic cancers. Given its prominence in mutation avoidance and its ability to target a range of DNA lesions, MMR has been under investigation in studies of ageing mechanisms. This review summarizes what is known about the molecular details of the MMR pathway and the role of MMR proteins in cancer susceptibility and ageing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Enzimas Reparadoras do DNA
/
Proteínas de Ligação a DNA
/
Reparo de Erro de Pareamento de DNA
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos