A phase I trial of pre-operative radiotherapy for prostate cancer: clinical and translational studies.
Radiother Oncol
; 88(1): 53-60, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18423916
ABSTRACT
BACKGROUND AND PURPOSE:
Selected patients undergoing radical prostatectomy for localized prostate cancer can be at high-risk for pT3 disease and require subsequent radiotherapy. In a phase I trial, we investigated the feasibility of pre-operative radiotherapy for this patient subset. MATERIALS ANDMETHODS:
Eligibility criteria were T1/T2N0M0 tumors plus (i) Gleason >or=7, PSA>10 ng/ml and <35 ng/ml, or (ii), PSA >15 ng/ml and less <35 ng/ml (any Gleason). Patients received 25 Gy in five fractions of radiotherapy followed by radical prostatectomy. Trial endpoints included intra-operative morbidity and late toxicity following combined treatment. We also stained pre- and post-radiotherapy prostate samples for DNA damage response proteins.RESULTS:
Between 2001 and 2004, 15 patients were entered on trial. Thirteen patients completed combined-modality treatment. Only one patient had signs of intra-operative inflammation. No patient had post-operative complication. There was no severe late gastrointestinal toxicity. Late genitourinary toxicity consisted of severe urinary incontinence in 2 of 13 patients. From a translational standpoint, irradiated prostate tumor tissues had long-term activation of the CDK-inhibitor p21(WAF) associated with reduced cell proliferation.CONCLUSION:
Intra-operative morbidity is low following short-course, pre-operative radiotherapy. A phase II trial is planned to fully document biochemical response with this combined-modality approach.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Adenocarcinoma
/
Radioterapia Conformacional
Limite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Radiother Oncol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Canadá