Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II.
J Am Chem Soc
; 130(22): 6942-3, 2008 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-18461940
ABSTRACT
Cryptophanes represent an exciting class of xenon-encapsulating molecules that can be exploited as probes for nuclear magnetic resonance imaging. The 1.70 A resolution crystal structure of a cryptophane-derivatized benezenesulfonamide complexed with human carbonic anhydrase II shows how an encapsulated xenon atom can be directed to a specific biological target. The crystal structure confirms binding measurements indicating that the cryptophane cage does not strongly interact with the surface of the protein, which may enhance the sensitivity of 129Xe NMR spectroscopic measurements in solution.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Isótopos de Xenônio
/
Anidrase Carbônica II
/
Substâncias Macromoleculares
Limite:
Humans
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos