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Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves' disease.
Horst-Sikorska, Wanda; Ignaszak-Szczepaniak, Magdalena; Marcinkowska, Michalina; Kaczmarek, Marta; Stajgis, Malgorzata; Slomski, Ryszard.
Afiliação
  • Horst-Sikorska W; Department of Family Medicine, Poznan University of Medical Sciences, Poland. zmrw2l@amp.edu.pl
Acta Biochim Pol ; 55(2): 371-80, 2008.
Article em En | MEDLINE | ID: mdl-18506225
ABSTRACT
UNLABELLED Graves' (GD) hyperthyroidism induces accelerated bone turnover that leads to decreased bone mineral density (BMD). The role of the VDR gene in predisposition to primary osteoporosis has been recognized. Recent studies show associations between the VDR gene polymorphisms and susceptibility to autoimmune diseases. Here we analyzed if VDR gene polymorphisms BsmI, ApaI, TaqI, and FokI may predispose women with Graves' hyperthyroidism to BMD reduction or to disease development. The subjects were 75 premenopausal female Polish patients with GD and 163 healthy women. The genotyping was performed by the use of the restriction fragment length polymorphism analysis (RFLP). We studied the association of the VDR polymorphisms and their haplotypes with patients' BMD and also SNPs and haplotypes association with Graves' disease. We found a strong linkage disequilibrium for the BsmI, ApaI, and TaqI polymorphims that formed three most frequent haplotypes in Graves' women baT (47.9%), BAt (34.9%), and bAT (16.4%). We did not show statistically significant association of analyzed VDR polymorphisms or haplotypes with decreased bone mineral density in Graves' patients. However, the presence of F allele had a weak tendency to be associated with Graves' disease (with OR=1.93; 95% CI 0.97-3.84; p=0.058). IN

CONCLUSION:

VDR gene polymorphisms do not predict the risk of decreased BMD in Polish women with Graves'. It may be speculated that the F allele carriers of the VDR-FokI polymorphism are predisposed to Graves' disease development.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Doença de Graves / Receptores de Calcitriol Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: Europa Idioma: En Revista: Acta Biochim Pol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Polônia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Doença de Graves / Receptores de Calcitriol Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: Europa Idioma: En Revista: Acta Biochim Pol Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Polônia