Computational analysis suggests beta-defensins are processed to mature peptides by signal peptidase.
Protein Pept Lett
; 15(5): 536-40, 2008.
Article
em En
| MEDLINE
| ID: mdl-18537746
ABSTRACT
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serina Endopeptidases
/
Processamento de Proteína Pós-Traducional
/
Biologia Computacional
/
Beta-Defensinas
/
Proteínas de Membrana
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Protein Pept Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos