Pediatric morphea (localized scleroderma): review of 136 patients.
J Am Acad Dermatol
; 59(3): 385-96, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18571769
ABSTRACT
BACKGROUND:
Morphea is an autoimmune inflammatory sclerosing disorder that may cause permanent functional disability and disfigurement.OBJECTIVES:
We sought to determine the clinical features of morphea in a large pediatric cohort.METHODS:
We conducted a retrospective chart review of 136 pediatric patients with morphea from one center, 1989 to 2006.RESULTS:
Most children showed linear morphea, with a disproportionately high number of Caucasian and female patients. Two patients with rapidly progressing generalized or extensive linear morphea and arthralgias developed restrictive pulmonary disease. Initial oral corticosteroid treatment and long-term methotrexate administration stabilized and/or led to disease improvement in most patients with aggressive disease.LIMITATIONS:
Retrospective analysis, relatively small sample size, and risk of a selected referral population to the single site are limitations.CONCLUSIONS:
These data suggest an increased prevalence of morphea in Caucasian girls, and support methotrexate as treatment for problematic forms. Visceral manifestations rarely occur; the presence of progressive problematic cutaneous disease and arthralgias should trigger closer patient monitoring.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esclerodermia Localizada
/
Metotrexato
/
População Branca
/
Fármacos Dermatológicos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
/
Female
/
Humans
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Infant
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Male
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos