Nano-sized micelles of block copolymers of methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-2-hydroxyethyl cellulose for doxorubicin delivery.
J Nanosci Nanotechnol
; 8(5): 2362-8, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18572650
ABSTRACT
The amphiphilic block copolymers methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) was grafted to 2-hydroxyethyl cellulose to produce the water-soluble copolymers. Doxorubicin loaded nanoparticles were prepared by dialysis method and the sizes of nanoparticles were determined by dynamic light scattering in solution and atomic force microscopes. As results the sizes were detected in a range of 197.4 to 340.7 nm. The in-vitro release of Dox was studied in phosphate and acetate buffered solution at 37 degrees C. The results showed that 43 and 53% of Dox remained after an incubation period of 7 days. The cytotoxicity of Dox loaded micelles was investigated in two different human MCF-7/wild type and MCF-7/Adriamycin drug resistant cells lines. The Dox-loaded micelles showed reduced cytotoxicity compared to free Dox in MCF-7/wild type and MCF-7/Adriamycin drug resistant cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
/
Polietilenoglicóis
/
Doxorrubicina
/
Celulose
/
Nanoestruturas
/
Micelas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Nanosci Nanotechnol
Ano de publicação:
2008
Tipo de documento:
Article