Discrimination learning in Rora(sg) and Grid2(ho) mutant mice.
Neurobiol Learn Mem
; 90(2): 472-4, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18583162
Rora(sg) mutants with mild cerebellar granule cell degeneration were compared to Grid2(ho) mutants with more severe granule cell degeneration as well as Purkinle cell atrophy for left-right and dark-light discrimination learning tasks in a water-filled T-maze. The acquisition rate of both cerebellar mutants was slowed down during light-dark but not left-right discrimination learning. However, the mutants were impaired in reversal training in both tasks. In contrast, neither mutant differed from controls in passive avoidance learning. These results indicate that mice with cerebellar damage are affected in some instrumental learning tasks and have perseverative tendencies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientação
/
Degenerações Espinocerebelares
/
Transativadores
/
Receptores Citoplasmáticos e Nucleares
/
Aprendizagem em Labirinto
/
Proteínas Adaptadoras de Transdução de Sinal
/
Aprendizagem por Discriminação
/
Reação de Fuga
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Learn Mem
Assunto da revista:
BIOLOGIA
/
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Canadá