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Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.
Li, Hao; Radford, Jonathan C; Ragusa, Michael J; Shea, Katherine L; McKercher, Scott R; Zaremba, Jeffrey D; Soussou, Walid; Nie, Zhiguo; Kang, Yeon-Joo; Nakanishi, Nobuki; Okamoto, Shu-ichi; Roberts, Amanda J; Schwarz, John J; Lipton, Stuart A.
Afiliação
  • Li H; Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
Proc Natl Acad Sci U S A ; 105(27): 9397-402, 2008 Jul 08.
Article em En | MEDLINE | ID: mdl-18599437
ABSTRACT
Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex. Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in aberrant compaction and smaller somal size. NSC proliferation and survival were not affected. Conditional null mice surviving to adulthood manifested more immature electrophysiological network properties and severe behavioral deficits reminiscent of Rett syndrome, an autism-related disorder. Our data support a crucial role for MEF2C in programming early neuronal differentiation and proper distribution within the layers of the neocortex.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Fatores de Transcrição / Diferenciação Celular / Fatores de Regulação Miogênica / Neurônios Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Fatores de Transcrição / Diferenciação Celular / Fatores de Regulação Miogênica / Neurônios Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Estados Unidos