[Risk factors for side effects due to the use of antituberculous drugs in elderly patients].
Kekkaku
; 83(6): 457-63, 2008 Jun.
Article
em Ja
| MEDLINE
| ID: mdl-18634450
ABSTRACT
PURPOSE:
This study was designed to evaluate incidence of clinical risk factors for side effects due to the use of antituberculous drugs.METHOD:
We retrospectively analyzed clinical records of 229 elderly patients with tuberculosis treated at our hospital.RESULTS:
Temporary stop of antituberculous therapy proved to be needed because of side effects in 77 patients (33.6%). Adverse effects leading to drug discontinuation were liver dysfunction (15.7%), gastrointestinal dysfunction (7.0%), and skin rash (5.7%); other effects accounted for discontinuation in 5.2%. Risk factors for liver dysfunction according to Cox proportional hazards regression analysis were complications of HCV infection (hazard ratio or HR, 2.97; 95% confidence interval or CI, 1.20 to 7.38; p=0.019); hepaocellular injury present at admission (HR, 3.37; 95% CI, 1.56 to 7.29; p=0.002); and dose of isoniazid (per mg/kg, HR, 1.40; 95% CI, 1.05 to 1.85; p=0.02). Body mass index was a risk factor for gastrointestinal dysfunction (per kg/m2, HR, 0.83; 95% CI, 0.70 to 0.98; p=0.026).CONCLUSION:
Such identification of risk factors for side effects from antituberculous therapy in elderly tuberculosis patients would minimize adverse effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antituberculosos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
Ja
Revista:
Kekkaku
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão