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[Molecular medicine in thyroid surgery]. / Medicina molecolare in chirurgia della tiroide.
Moretti, Sonia; Barbi, Flavia; Tavano, Maria; Calzolari, Filippo; Misso, Claudia; Lucchini, Roberta; Monacelli, Massimo; D'Ajello, Michele; Puxeddu, Efisio; Avenia, Nicola.
Afiliação
  • Moretti S; Dipartimento di Medicina Interna, Centro di Riferimento Regionale per l'Endocrinochirurgia, Università degli Studi di Perugia, Perugia.
Chir Ital ; 60(2): 165-78, 2008.
Article em It | MEDLINE | ID: mdl-18689164
ABSTRACT
Cancer originates from a single cell which, through the acquisition of mutations in genes for key growth and survival factors, undergoes clonal expansion. Study of the genome allowed the detection of genes whose mutation is involved in tumour formation. In detail, in most thyroid neoplasms we are now able to identify the genes which cause cancer initiation. Moreover, correlations between mutations and clinico-pathological features of the tumours have been revealed. Thus, the genetic study of tumours is not anymore only a scientific curiosity, but a useful tool for the formulation of the more efficacious therapeutic and follow-up strategies. In this review we will summarize the more recent molecular medicine acquisitions in the thyroid cancer field and will describe their present and eventually future impact on the activity of the endocrine surgeon.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide Tipo de estudo: Prognostic_studies Limite: Humans Idioma: It Revista: Chir Ital Ano de publicação: 2008 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide Tipo de estudo: Prognostic_studies Limite: Humans Idioma: It Revista: Chir Ital Ano de publicação: 2008 Tipo de documento: Article