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[Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets].
Qu, Lu; Zheng, Hang-Sheng; Feng, Nian-Ping; Li, Song-Ming.
Afiliação
  • Qu L; Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zhongguo Zhong Yao Za Zhi ; 33(10): 1168-70, 2008 May.
Article em Zh | MEDLINE | ID: mdl-18720869
OBJECTIVE: To develop an HPLC method to determine vitexin-rhamnoside in plasma of Beagle dogs and study the pharmacokinetics and bioavailability of Yixintong sustained release tablets in Beagle dogs. METHOD: A newly-developed HPLC method using C18 column and methanol-acetonitrile-tetrahydrogenfuran-0.5% acetic acid (1:1:19.4:78.6) as mobile phase was validated, and then was employed to determine vitexin-rhamnoside in plasma of Beagle dogs after oral administration of Yixintong sustained release tablets and general tablets. The main pharmacokinetic parameters were estimated by pharmacokinetic program 3p87. The non-compartmental pharmacokinetic parameters were also calculated on basis of the statistic moment theory. RESULT: The pharmacokinetic profiles of Yixintong sustained release tablets and the general tablets were fitted to a one-and two-compartment open model, respectively. The T1/2, Tmax, AUC0-infinity and MRT for Yixintong sustained release tablets were 5.22 h, 4.0 h, 6,792.75 ng x h x mL(-1) and 8.4 h, respectively, compared with 8.94 h, 1.0 h, 5,880.4 ng x h x mL(-1) and 6.1 h for the general tablets. The relative bioavailability of the Yixintong sustained release tablets was 115.5% in Beagle dogs. CONCLUSION: The sustained-release characteristic of Yixintong sustained release tablets were confirmed by pharmacokinetic study.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasma / Medicamentos de Ervas Chinesas / Apigenina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Ano de publicação: 2008 Tipo de documento: Article País de afiliação: China
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasma / Medicamentos de Ervas Chinesas / Apigenina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Ano de publicação: 2008 Tipo de documento: Article País de afiliação: China