Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

Nolan, L; Johnson, P W M; Ganesan, A; Packham, G; Crabb, S J

Nolan, L; Johnson, P W M; Ganesan, A; Packham, G; Crabb, S J.

Afiliação

Nolan L; Cancer Research UK Clinical Centre, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

Br J Cancer ; 99(5): 689-94, 2008 Sep 02.

Article em En | MEDLINE | ID: mdl-18728657

ABSTRACT

ABSTRACT

Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing. This review highlights the promising data for their combination with a wide range of established and novel anticancer agents and discusses the mechanisms that underpin these interactions.

Assuntos

Antineoplásicos/uso terapêutico; Inibidores Enzimáticos/uso terapêutico; Inibidores de Histona Desacetilases; Neoplasias/tratamento farmacológico; Antineoplásicos/administração & dosagem; Protocolos de Quimioterapia Combinada Antineoplásica; Inibidores Enzimáticos/administração & dosagem; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Inibidores de Histona Desacetilases / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Br J Cancer Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Reino Unido

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