[Ulcerous colitis and infection with cytomegalovirus, herpes simplex virus and clostridium difficile]. / Schwere Colitis ulcerosa und Infektion mit Cytomegalieviren, Herpes-simplex-Viren und Clostridium difficile.
Z Gastroenterol
; 46(8): 780-3, 2008 Aug.
Article
em De
| MEDLINE
| ID: mdl-18759202
ABSTRACT
The treatment of severe flares of ulcerative colitis is based on systemic corticosteroids, immunomodulators such as cyclosporine and azathioprine and in some cases TNF-alpha-antagonists, respectively. These immunosuppressed patients are susceptible for infectious pathogens. Here we report the case of a patient with a severe flare of ulcerative colitis that was first treated with systemic corticosteroids combined with immunomodulators and subsequent with infliximab. The patient then experienced an infection with Clostridium difficile and cytomegalovirus of the colon and a Herpes simplex esophagitis, respectively. After specific treatment the patient responded well to the immunosuppressive therapy. This case illustrates that infections have to be considered before systemic treatment of an acute flare of ulcerative colitis is instituted especially in the case of disease activation during immunosuppressive treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Oportunistas
/
Colite Ulcerativa
/
Clostridioides difficile
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Infecções por Clostridium
/
Infecções por Citomegalovirus
/
Herpes Simples
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Z Gastroenterol
Ano de publicação:
2008
Tipo de documento:
Article